Risk factors of postoperative nosocomial pneumonia in stage I-IIIa lung cancer patients.

Zeng Wang,Fei-Yan Li,Neng-Ming Lin,Liang Shi,Xin-Jun Cai

doi:10.7314/apjcp.2014.15.7.3071

Abstract

To investigate the related risk factors of postoperative nosocomial pneumonia (POP) in patients with I-IIIa lung cancer. Medical records of 511 patients who underwent resection for lung cancer between January 2012 to December 2012 were retrospectively reviewed. Risk factors of postoperative pneumonia were identified and evaluated by univariate and multivariate analyses. The incidence of postoperative pneumonia in these lung cancer patients was 2.9% (15 cases). Compared with 496 patients who had no pneumonia infection after operation, older age (>60), histopathological type of squamous cell carcinoma and longer surgery time (>3h) were significant risk factors by univariate analysis. Other potential risk factors such as alcohol consumption, history of smoking, hypersensitivity, hypertension, diabetes mellitus and so on were not showed such significance in this study. Further, the multivariate analysis revealed that old age (>60 years) (OR 5.813, p=0.018) and histopathological type of squamous cell carcinoma (OR 5.831, p<0.001) were also statistically significant independent risk factors for postoperative pneumonia. This study demonstrated that being old aged (>60 years) and having squamous cell carcinoma histopathological type might be important factors in determining the risk of postoperative pneumonia in lung cancer patients after surgery.

Highlights

For several decades, lung carcinoma has been the most commonly diagnosed malignancy and the leading cause of cancer-related mortality
This study demonstrated that being old aged (>60 years) and having squamous cell carcinoma histopathological type might be important factors in determining the risk of postoperative pneumonia in lung cancer patients after surgery
The incidence of postoperative pneumonia in our study (2.9%) is lower than the previously reported rates of 5 to 20% (Arozullah et al, 2001; Belda et al, 2005) the disparities may be explained by different definitions and diagnostic tests of pneumonia among studies

Summary

Introduction

Lung carcinoma has been the most commonly diagnosed malignancy and the leading cause of cancer-related mortality. The general incidence of postoperative complications after thoracic surgery is approximately 30%, making it the most frequent and the most common causes of mortality after lung resection (Stephan et al, 2000; Kyriazi and Theodoulou, 2013). Compared with 496 patients who had no pneumonia infection after operation, older age (>60), histopathological type of squamous cell carcinoma and longer surgery time (>3h) were significant risk factors by univariate analysis. Conclusions: This study demonstrated that being old aged (>60 years) and having squamous cell carcinoma histopathological type might be important factors in determining the risk of postoperative pneumonia in lung cancer patients after surgery

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