Risk factors of partial response of primary liver cancer after percutaneous radiofrequency ablation

Abstract

Objective To determine the risk factors of the partial response of primary liver cancer after percutaneous radiofrequency ablation(PRFA).Methods From December 1999 to April 2007,we treated 2331 tumors in 1142 eases of primary liver cancer with PRFA.The 192 of the 2331 tumors achieved a partial response(PR).We investigated the relationship between 10 pretreatment factors and the partial response of PRFA.Results The overall partial response rate was 8.2%within 2 months after PRFA.Tumor size,tumor location,growth pattern,TACE before PRFA,the elec-trode pattern and legible orientation of tumor under ultrasound were significantly associated with a higher partial response rate(P=0.000,P=0.004,P=0.014,P=0.001 and P=0.000,respectively).However,only the tumor size,tumor location,growth pattern and TACE before PRFA were found to be independent risk factors for the partial response of primary liver cancer after percutaneous radiofre-quencv ablation by Logistic regression model.Conclusion The tumor size,tumor location,growth pattern of tumor and TACE before PRFA treatment influence the local efficacy of PRFA fOr primary liver cancer. Key words: Carcinoma,hepatocellular; Percutaneous radiofrequency ablation; Partial response