Abstract
Multidrug-resistant tuberculosis has been increased worldwide which is a severe problem. A case-control study was carried out among 50 MDR-TB cases and 63 drug susceptible controls to identify risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Lumbini Zone. Irregularity in taking medicine (OR=2.36), large family size (OR=2.40), farming as occupation (OR=2.83), history of TB and bovine at home (OR=6.5) were statistically associated with MDR-TB. Most of the MDR-TB cases were males (82%) and individual with the age group 21-30 years (40%) were highly infected with MDR-TBInt. J. Appl. Sci. Biotechnol. Vol 5(4): 548-554
Highlights
Multi-drug-resistant tuberculosis (MDR-TB) is defined as tuberculosis that is resistant to at least isoniazid (INH) and rifampicin (RMP), the two most powerful first-line treatment anti-TB drugs
Age and Sex Wise Distribution of MDR-TB Patients in Lumbini Zone Out of 50 MDR-TB patients, highest percentage of MDRTB (40%) were found within the age group 21-30 years followed by the age group 41-50 years (20%) and 31-40 years with 18% while rest of the age groups of pulmonary tuberculosis (PTB) patients had developed comparatively less MDR-TB (6 to 8%) (Fig.1)
Risk Factors Associated With the Development of MDRTB A case-control study was designed to identify the risk factors for the development of MDR-TB among PTB patients
Summary
Multi-drug-resistant tuberculosis (MDR-TB) is defined as tuberculosis that is resistant to at least isoniazid (INH) and rifampicin (RMP), the two most powerful first-line treatment anti-TB drugs. Tuberculosis is closely linked to both overcrowding and malnutrition, making it one of the principal diseases of poverty (Lawn and Zumla, 2011) Those at high risk include: people who inject illicit drugs, inhabitants and employees of locales where vulnerable people gather (e.g. prisons and homeless shelters), medically underprivileged and resource-poor communities, high-risk ethnic minorities, children in close contact with high-risk category patients, and health-care providers serving these patients (Griffith and Kerr, 1996).Other disease states can increase the risk of developing tuberculosis. Vol 5(4): 548-554 factors, especially in the developed world (Lawn and Zumla 2011)
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