Abstract
Background and Objective:Knee osteoarthritis is one of the most common rheumatologic problems. To investigate risk factors related to the knee osteoarthritis a case-control study was performed using cases diagnosed in the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) study, stage I.Methods:Using data from the 2012 COPCORD study, stage-I that was conducted in Sanandaj, northwestern of Iran, we runned a case-control study in 2014-2015. Cases were 700 knee osteoarthritis using American College of Rheumatology (ACR) criteria, frequency matched with 700 healthy controls that were randomly selected from the general population.Results:In multivariate analysis, statistical significant relation was observed between knee OA and some studied factors such as body mass index (P <0.001), lodging (living in highland vs. plain) (P <0.001), type of used toilet (regular vs. toilet) (P <0.001), history of using high-heeled shoes (>3 cm) (P = 0.005), history of knee Injury (P = 0.04), history of lower limb fracture (P = 0.02), Number of pregnancies (P <0.001) and history of pain and swelling (lasting for one months) (P = 0.04).Conclusions:Living in highland area, using regular toilet, having knee injury and lower limb fracture in the past were most significant associated factors with occurrence of knee osteoarthritis.
Highlights
Osteoarthritis (OA) is the most widespread rheumatic illness in human populations leading to chronic pains and severe disabilities worldwide.[1]
The ethnicity of study setting is Kurdish, a subgroup of the Caucasians with total population of 311,446 living in 81,380 households. Cases were those who were diagnosed as knee OA using American College of Rheumatology (ACR) criteria in Sanandaj COPCORD study.[6]
As shown in Table-III, the chance of knee OA occurrence in persons which lived in highland is significantly 5.67 (4.40 – 7.31) times higher than those lived in plain area
Summary
Osteoarthritis (OA) is the most widespread rheumatic illness in human populations leading to chronic pains and severe disabilities worldwide.[1]. To investigate risk factors related to the knee osteoarthritis a case-control study was performed using cases diagnosed in the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) study, stage I. Results: In multivariate analysis, statistical significant relation was observed between knee OA and some studied factors such as body mass index (P < 0.001), lodging (living in highland vs plain) (P 3 cm) (P = 0.005), history of knee Injury (P = 0.04), history of lower limb fracture (P = 0.02), Number of pregnancies (P
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