Abstract
BackgroundEndometrial hyperplasia (EH) is commonly-seen in the patients with endometrial cancer (EC), we aimed to evaluated the risk factors of EC in patients with EH, to provide evidence to the clinical prevention and treatment of EC.MethodsThis study was a retrospective study design. EH patients confirmed by pathological examinations and treated with hysterectomy in our hospital from June 1, 2018 to February 28, 2021 were included. The clinical characteristics of EC and no-EC patients were compared and analyzed. Logistics regression analyses were conducted to evaluate the risk factors of EC in patients with EH.ResultsA total of 228 EH patients were included, the incidence of EC in the EH patients was 31.58%. There were significant differences in the age, BMI, diabetes, hypertension and pathology of EH between EC and no EC groups (all P < 0.05), no significant differences in the hyperlipidemia, preoperative CA125, number of deliveries, menopause and endometrial thickness between EC and no EC groups were found (all P > 0.05). Logistic regression analyses indicated that age > 50 y (OR 3.064, 95% CI 1.945–5.931), BMI ≥ 25 kg/m2 (OR 2.705, 95% CI 1.121–3.889), diabetes (OR 3.049, 95% CI 1.781–5.114), hypertension (OR 2.725, 95% CI 1.108–3.431) and severe hyperplasia (OR 3.181, 95% CI 1.496–4.228) were the risk factors of EC in patients with EH (all P < 0.05).ConclusionsThe risk of EC in EH patients is high, especially for those patients with age > 50 y, BMI ≥ 25 kg/m2, diabetes, hypertension and severe hyperplasia, special attentions should be paid for occurrence of EC and early diagnosis and early treatment are needed for those patients.
Highlights
Endometrial hyperplasia (EH) is commonly-seen in the patients with endometrial cancer (EC), we aimed to evaluated the risk factors of EC in patients with EH, to provide evidence to the clinical prevention and treatment of EC
The criterial for patient inclusion were: the endometrial thickness was determined by the B-ultrasound and pathological examinations, the ultrasound examinations of all selected patients were performed by the same group of sonographers in our hospital; patients underwent hysterectomy treatment in our hospital, and there were complete postoperative pathological reports; there was no history of hormone replacement therapy in the past 1 year
Discussions The results of this present study have found that the incidence of EC in the EH patients was 31.58%, which is similar to previous reports [14, 15]
Summary
Endometrial hyperplasia (EH) is commonly-seen in the patients with endometrial cancer (EC), we aimed to evaluated the risk factors of EC in patients with EH, to provide evidence to the clinical prevention and treatment of EC. How to identify high-risk patients with EC from patients with EH, is important to guide clinical treatment decisions and improve the prognosis of patients. This present study analyzed the clinicopathological data of patients diagnosed with EH before hysterectomy, aimed to explore the high-risk factors of EC in patients with EH, to provide evidence support to the early prevention and clinical treatment of EC
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