Abstract
Background: The frequency of patients developing Breast Cancer (BC) among all other types of cancers exceeds 35% in Western Algeria. The main objective here was to determine which risk factors were associated with this high frequency of BC occurrence in young adult women (<40 years old) in Western Algeria. Methods: A BC case-control study matching with the woman age was conducted. The total number of participants was 484 women from Western Algeria. Inclusion criteria were BC and age <40 and women older than 40 or without documented BC were excluded. Results: Univariable analysis showed that i) there was an increased risk of BC; OR = 1.77 [1.06 to 2.93] in married women using oral contraception drugs; ii) in contrast there was a lesser risk; OR = 0.43 [0.28 to 0.65] of BC in multiparous compared to nulliparous women; iii) similarly there was a lesser risk; OR = 0.45 [0.26 to 0.76] of BC in married, divorced and widowed women compared to single women. Multivariable analysis showed a higher risk; OR = 2.34 [1.05 to 5.22] of BC in non-breastfeeding than lactating women. Conclusion: The use of oral contraception drugs, nulliparity, lack of breastfeeding and the single unmarried status are risk factors associated with increased BC in young adult women (<40) from Western Algeria.
Highlights
Cancer remains the highest threat to human health, since in 2018 over 18 million individuals developed cancer worldwide [1]
The incidence of Breast Cancer (BC) is in a continuous increase worldwide in all ages individuals including in Algeria [1]
The high incidence of BC in women of North Africa and Algeria highlights the need of a close investigation of the risk factors associated with the occurrence of this malignancy and that can be used for early disease detection [3]
Summary
Cancer remains the highest threat to human health, since in 2018 over 18 million individuals developed cancer worldwide [1]. Breast cancer (BC) is one of the most frequent cancers in women all over the world, associated with a high mortality. The incidence of BC is in a continuous increase worldwide in all ages individuals including in Algeria [1]. With 36.1% frequency among cancers in women living in western Algeria, according to the cancer file records, BC remains the most frequent malignancy in this women population during the last three years (2016-2018), affecting 30 out of 100 000 women yearly. The main objective here was to determine which risk factors were associated with this high frequency of BC occurrence in young adult women (
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