Risk factors of biochemical recurrence after radical prostatectomy : clinical analysis of 301 cases in a single-center

Abstract

Objective To analyze the risk factors of biochemical recurrence after radical prostatectomy.Methods Data were prospectively collected for 301 consecutive patients undergoing radical prostatectomy between Jan.2001 and Feb.2010.The average patient age was 69 (ranged from 51 to 81) years.Of whom,26 cases were diagnosed after TURP,and 275 cases were diagnosed by prostate biopsy.135 cases were with Gleason score less than 7,while 166 cases were with higher Gleason score.There were 26 cases in clinical stage T1a-T1b(8.6％),while 91 cases in T1c(30.2％),64 cases in T2a(21.3％),100 cases in T2b (33.2％),12 cases in T2c(4.0％),8 cases in T3a(2.7％),respectively.These patients were divided into older group (aged more than 70 years) and younger group (aged less than 70 years).There was significant difference in PSA (P=0.003) between the two groups,while there was no difference between their Gleason score (P=0.138) and clinical stage (P=0.156).All radical prostatectomies were performed by three experienced surgeons through extraperitoneal approach.Patients who accepted radical prostatectomy in our center had higher PSA and Gleason score than that of the foreign cases.The differences between the two groups in the age,PSA,clinical stage,positive biopsy core rate were compared.Results By analyzing the data of these 301 patients,we found that PSA,age,clinical stage,positive biopsy core rate could affect the biochemical recurrence after radical prostatectomy in prostate cancer patients.Besides,elderly patients had significantly higher biochemical recurrence rate (93.0％) than younger patients (87.0％).Conclusions PSA,age,clinical stage,positive biopsy core rate are the risk factors of biochemical recurrence after radical prostatectomy.However,Gleason score had no significant effect on biochemical recurrence in prostate cancer patients. Key words: Prostatic neoplasms; Biochemical recurrence; Age; Radical prostatectomy