Abstract

Objective To evaluate the risk factors of aortic and pulmonary regurgitation after arterial switch operation (ASO), and to assess the midterm follow-up results after ASO. MethodsFrom December 1999 to December 2007, 288 patients recovered after ASO in our center. Two hundred and twenty eight patients were followed up. The Mean follow-up time was 20.4±18.6 months. The pre-and postoperative aortic and pulmonary valve function were analyzed by echocardiography.Results According to the patterns of cardiac malformation, the patients were divided into 4 groups: the Stage-Switch group, the Taussig-Bing group, the Transposition of the Great Arteries with ventricular septal defect (TGA/VSD) group, and the Great Arteries with Intact Ventricular Septum (TGA/IVS) group. After ASO, the morbility of aortic regurgitation (AR) was significantly different between the 4 groups (P=0.010). There is no difference in the morbility of pulmonary regurgitation (PR) between the 4 groups (P>0.05). Multivariate analysis suggested the risk factors assosiated with AR development during follow-up were the operation age (>60 days), AO/PA (>1.10), and AR at discharge. Univariate analysis revealed the PR at discharge was related to the development of PR during follow-up. Conclusions The morbility of AR increases with the length of follow-up. Mild regurgitation after ASO can alleviate or even disappear during the follow-up. The patient underwent ASO should be followed-up perodically in order to evaluate the valve function and healing of aortic and pulmonary anastomosis. Key words: Aortic valve insufficiency; Pulmonary valve insufficiency

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