Abstract
Background and aims: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) which involves the rectum and colonic mucosa, and is often constantly expanding. Few data are available on risk factors in Chaharmahal and Bakhtiari province. Therefore, the aim of this study was to investigate the association between potential risk factors and UC in Shahrekord. Methods: A case-control study was conducted on patients diagnosed with UC. Overall, 27 new cases of UC and 54 healthy controls in the age range of 20–80 years were studied. Participants were recruited from Pathologic Centers in Shahrekord in 2018. Chi-square test and t test and were used. Logistic regression model was employed to analyze the association between risk factors and UC disease. Results: The mean age at diagnosis was 41.74 years (SD: 7.16 years) and 44.94 years (SD: 6.67 years) for case and control subjects, respectively. Moreover, univariate and multiple odds ratio (OR) showed that there was no significant association between UC and any of the risk factors including gender, marital status, education, diastolic blood pressure, history of diabetes, history of hypertension, permanent use of piped water, night shift work, history of thyroid diseases, depression, history of fatty liver disease, history of kidney stones, and sleep time and wake-up time in the morning. Conclusion: Generally, no significant association was observed between UC and the variables in the present study. Thus, further studies with larger sample size are necessary to better understand the other risk factors and environmental determinants of UC.
Highlights
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) which involves the rectum and colonic mucosa, and is often constantly expanding.[1]
The normal diastolic blood pressures were 94.0 mmHg and 95.2 mmHg for the case and control participants, respectively (P value = 0.66); 91.4% had a history of diabetes (32.4% for cases and 67.6% for controls, P value = 66), 88.9% had a history of hypertension (36.1% for cases and 73.9% for controls, P value = 0.13), 80.2% had a history of fatty liver disease (30.8 for cases and 69.2% for controls, P value = 0.32), 88.0% had a history of thyroid disease (31.9% for cases and 68.1% for controls, P value = 0.45), 72.8% had a history of kidney stones (35.6% for cases and 64.4% for controls, P value = 0.48), and 88.9% had experience of depression (33.8% for cases and 66.3% for controls, P value = 0.13)
There were no significant differences between the two groups in terms of the risk factors
Summary
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) which involves the rectum and colonic mucosa, and is often constantly expanding.[1] UC is characterized by diarrhoea, weight loss, pain in the lower left abdomen, rectal bleeding,[2] and remission and frequent relapses.[3] The disease can lead to complication, surgery, hospitalization, and death It greatly influences the activity and quality of life of the patients.[4,5] the etiology of UC has not yet been well known, it seems that genetic, environmental, and immunoregulatory factors affect it.[6,7] The worldwide incidence and prevalence of IBD is rising, and the incidence is higher in industrialised countries compared to developing countries, despite limited information from developing countries.[8] The geographical variability and rising incidence of UC suggest that environmental factors are involved in the etiology of the IBD8,9; limited information is available in this regard.[10] few data are available on the risk factors associated in Chaharmahal and Bakhtiari Province.
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