Abstract
BackgroundTo evaluate the potential risk factor of visual-threatening posterior capsule opacification (PCO) via the analysis of National Health Insurance Research Database in Taiwan.Patients and methodsA total of 8571 patients (3767 male and 4804 female) were recruited in the study group and 17,142 patients (7534 male and 9608 female) in the control group. Patients undergoing cataract surgery, acrysof single-piece intraocular lens implantation and Nd:YAG capsulotomy were selected as the study group. After exclusion which aimed to standardize the ocular condition and exclude the possibility that patients undergoing cataract surgery and Nd:YAG capsulotomy in different eyes, each patient in the study group was age-gender matched to two patients undergoing cataract surgery but without Nd:YAG capsulotomy. The demographic data, systemic disease, and ocular co-morbidities were obtained and analyzed. Adjusted odds ratio (OR) of each demographic data and co-morbidities to the development of visual-threatening PCO, and adjusted OR of co-morbidities to visual-threatening PCO develop within 1 year postoperatively.ResultsThe dry eye disease (DED), glaucoma, uveitis, age-related macular degeneration (AMD), hyperlipidemia, peptic ulcer disease and liver disease showed significant crude OR while the DED, glaucoma, AMD, hyperlipidemia and peptic ulcer disease revealed a significant adjusted OR. In the subgroup analysis, the DED, glaucoma, AMD, and hyperlipidemia still illustrated a higher adjusted OR to develop visual-threatening PCO within 1 year after the cataract surgery.ConclusionThe DED, glaucoma, AMD, hyperlipidemia and peptic ulcer disease may serve as the risk factor for the developing of visual-threatening PCO.
Highlights
To evaluate the potential risk factor of visual-threatening posterior capsule opacification (PCO) via the analysis of National Health Insurance Research Database in Taiwan
A total number of 8571 patients who received cataract surgery and Nd:YAG capsulotomy were enrolled in the study group while another 17,142 patients who received only cataract surgery without Nd:YAG capsulotomy were enrolled in the control group
The characteristics at baseline revealed an identical age and gender ratio due to matching, and a higher ratio of urbanization, dry eye disease (DED), glaucoma, uveitis, age-related macular degeneration (AMD), hyperlipidemia, peptic ulcer disease and liver disease were found in the study group (Table 1)
Summary
To evaluate the potential risk factor of visual-threatening posterior capsule opacification (PCO) via the analysis of National Health Insurance Research Database in Taiwan. Cataract surgery has been well-developed and widely applied for decades with excellent visual outcomes [1]. Since the possible pathophysiology of PCO included cell proliferation, transition and the activation of inflammatory mediators [10,11,12], it is possible that certain diseases that influence the intraocular condition may be the risk factors of PCO. The purpose of the current study was to evaluate the potential risk factors of visual-threatening PCO via the analysis of National Health Insurance Research Database (NHIRD) in Taiwan. The potential risk factors leading to PCO development within 1 year after the cataract surgery were investigated
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