Abstract
BackgroundThis study aimed to confirm the diagnostic accuracy of ultrasound (US) on gout and explore the potential risk factors for double-contour sign and tophi formation in gout patients.MethodsThe US analyses were performed on all knee, ankle, and first metatarsophalangeal (MTP 1) joints to reveal the type and location of lesions. While a questionnaire and blood biochemical index were used to explore the potential risk factors for double-contour sign and tophi in gout, the SPSS17.0 software was used for statistical analysis in the present study.ResultsTotally, 117 gout patients with 702 joints (38 lesions in knee joint, 93 lesions in ankle joint, and 112 lesions in MTP 1 joint) were enrolled in current analyses. Double-contour sign and joint effusion were the two most outstanding lesion manifestations in knee joints and ankle joints. Tophi and double-contour sign were the two most outstanding lesion manifestations in TMP 1 joints. Moreover, factors including uric acid (UA) level and the highest blood UA were potential risk factors of the double-contour sign, while age and history of US were potential risk factors for tophi.ConclusionUS was effective on the joints of gout patients. There was US sensitivity for tophi and double-contour sign in MTP 1 joints. The double-contour sign was a potential specific manifestation in knee joints and ankle joints. Furthermore, UA and highest blood UA level were potential risk factors for double-contour sign, while age and US history were potential risk factors for tophi.
Highlights
Gout is an inflammatory disorder characterized by hyperuricemia and the deposition of monosodium urate (MSU) crystals [1]
Baseline characteristics A total of 117 gout patients were enrolled in this study (114 males and 3 females, average age 40.32 ± 11.93 years)
The US detection was performed on a total of 234 knee joints, 234 ankle joints, and 234 MTP 1 joints (Table 1)
Summary
Gout is an inflammatory disorder characterized by hyperuricemia and the deposition of monosodium urate (MSU) crystals [1]. A high level UA accumulation in joints, tendons, and surrounding tissues can induce episodic gout flares, gouty arthropathy, and tophi formation [3]. Gout affects about 2% of the Western population at some point in their lives [4]. As the most common cause of inflammatory arthritis, gout has already caused a great social burden to human in recent decades [5]. It is necessary to develop novel strategies for gout treatment. This study aimed to confirm the diagnostic accuracy of ultrasound (US) on gout and explore the potential risk factors for double-contour sign and tophi formation in gout patients
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