Abstract
BackgroundUse of an implant is one of the risk factors for surgical site infection (SSI) after malignant bone tumor resection. We developed a new technique of coating titanium implant surfaces with iodine to prevent infection. In this retrospective study, we investigated the risk factors for SSI after malignant bone tumor resection and to evaluate the efficacy of iodine-coated implants for preventing SSI.MethodsData from 302 patients with malignant bone tumors who underwent malignant bone tumor resection and reconstruction were reviewed. Univariate analyses were performed, followed by multivariate analysis to identify risk factors for SSI based on the treatment and clinical characteristics.ResultsThe frequency of SSI was 10.9% (33/302 tumors). Pelvic bone tumor (OR: 4.8, 95% CI: 1.8–13.4) and an operative time ≥ 5 h (OR: 3.4, 95% CI: 1.2–9.6) were independent risk factors for SSI. An iodine-coated implant significantly decreased the risk of SSI (OR: 0.3, 95% CI: 0.1–0.9).ConclusionThe present data indicate that pelvic bone tumor and long operative time are risk factors for SSI after malignant bone tumor resection and reconstruction, and that iodine coating may be a promising technique for preventing SSI.
Highlights
Use of an implant is one of the risk factors for surgical site infection (SSI) after malignant bone tumor resection
Risk factors for surgical site infection Univariate analyses revealed that pelvic tumor, biological reconstruction, composite use of biological reconstruction and prosthetic replacement, additional surgery, and operative time ≥ 5 h were significantly correlated with an increased risk of SSI (Tables 3 and 4)
Multivariate analysis revealed that pelvic bone tumor and an operative time were independent risk factors for SSI (Table 5)
Summary
Use of an implant is one of the risk factors for surgical site infection (SSI) after malignant bone tumor resection. We developed a new technique of coating titanium implant surfaces with iodine to prevent infection. In this retrospective study, we investigated the risk factors for SSI after malignant bone tumor resection and to evaluate the efficacy of iodine-coated implants for preventing SSI. While determining the efficacy of iodine-coated implants in preventing SSI, the influence of several factors, such as preoperative chemotherapy and surgical site, should be considered. The objectives of this study were to determine risk factors associated with the development of SSI, and to investigate the efficacy of iodine-coated implants for preventing SSI after bone tumor resection
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