Risk factors for short and long-term great saphenous vein recanalization in patients treated with endovenous radiofrequency ablation.

Abstract

The aim of this retrospective single-center study is to describe and analyze short-, mid-, and long-term risk factors for great saphenous vein (GSV) recanalization after endovenous radiofrequency ablation (RFA). All consecutive patients with GSV incompetence and varicose veins underwent RFA were enrolled between 2009 and 2018. Data on demographic, pre- and postoperative color Doppler scan (CDUS) findings, perioperative complications, and follow-up were prospectively collected. Primary outcome was GSV recanalization rate at 1week after RFA. Secondary outcomes were postoperative complication rate, as well as GSV recanalization rate at 1, 3, and 5years after RFA. Risk factors for recanalization were also analyzed, for each follow-up assessment, identifying differences in recanalized (Rec) and non-recanalized (nRec) groups. During the study period, 1297 patients were treated. Among these, 1265 had at least 1week of follow-up. Mean follow-up time was 3.0 ± 1.9years. Recanalization rate at 1week, 1, 3, and 5years was 2.4%, 4.3%, 9.3%, and 17.5%, respectively. After multivariate analysis for each follow-up evaluation, CEAP classes C4 and 5, as well as preoperative GSV diameter >6mm and history of smoking were found to be independent predictors of recanalization. Furthermore, age >61years and postoperative complications such as pigmentation, edema, and paresthesia were found to be dependent risk factors. RFA remains a safe and durable technique to ablate incompetent GSV. Despite this, particular attention should be paid to patients with high CEAP classes to avoid short and long-term recanalization.