Abstract
BackgroundNeonatal thrombocytopenia (NT) (platelet count < 150 × 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants.MethodsDuring the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.ResultsIn total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P = 0.001) and had higher rates of mortality (P = 0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P = 0.001).ConclusionSevere NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with original disease of the babies.
Highlights
Thrombocytopenia, generally defined as a platelet count < 150 × 109/L, affects up to 35% of all patients admitted to the neonatal intensive care unit (NICU) [1, 2]
The main risk factors in full term (FT) infants were occult infection, placental insufficiency, and neonatal alloimmune thrombocytopenia (NAT), which differs from preterm risk factors, such as sepsis, TORCH infection, and necrotizing enterocolitis (NEC) [9]
Patient characteristics In total, 55 FT infants who met the inclusion criteria were included in this study
Summary
Thrombocytopenia, generally defined as a platelet count < 150 × 109/L, affects up to 35% of all patients admitted to the neonatal intensive care unit (NICU) [1, 2]. Early onset neonatal thrombocytopenia (NT), presenting in the first 72 h of life, is commonly associated withThere are two main underlying pathological mechanisms for NT: increased destruction/sequestration or decreased production of platelets. Thrombocytopenia, generally defined as a platelet count < 150 × 109/L, affects up to 35% of all patients admitted to the neonatal intensive care unit (NICU) [1, 2]. Onset neonatal thrombocytopenia (NT), presenting in the first 72 h of life, is commonly associated with. There are two main underlying pathological mechanisms for NT: increased destruction/sequestration or decreased production of platelets. NT occurs less frequency in full term (FT) infants than in preterm infants, as demonstrated in one cohort study where it was 2% [8]. Neonatal thrombocytopenia (NT) (platelet count < 150 × 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
