Risk Factors for Relapse of Human Brucellosis.

Mohammad Reza Hasanjani Roushan,Zeinab Mohseni Afshar,Soheil Ebrahimpour,Zahra Moulana

doi:10.5539/gjhs.v8n7p77

Mohammad Reza Hasanjani Roushan, Zeinab Mohseni Afshar + Show 2 more

Open Access

https://doi.org/10.5539/gjhs.v8n7p77

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Abstract

Background & Propose:Brucellosis is serious disease around the world, especially in underdeveloped countries. Relapse is major problem in therapy of brucellosis. This study aimed to evaluate risk factors of relapse after treatment in patients.Methods:It is a descriptive-analytic study from 1990 to 2014, in Ayatolla Rohani hospital in Babol, Iran. We studied 980 patients with brucellosis. The studied community included patients infected with brucellosis and the required information was gathered based on their hospital files. The base for recognizing Malta fever were clinical symptoms and Para-clinical sign congruent with infection like as, titer SAT>1:320 and 2-ME>1:160. Patients with relapse and patients without relapse were placed separately in two groups. The data were statistically compared with Spss 16, by Chi-square and Cox–regression tests.Results:Based on this study, treatment regimen is a preventive factor (P=0.000). Moreover, Based on some statistical methods, regimens no. 3 and 4 were introduce preventive factors (P=0.001) and (P=0.004). It should also be noted that findings the same statistical model, factors like gender, age, residence, professional contacts, complications and delay in treatment were also analyzed but none of them are considered as preventive factors.Conclusion:Based our finding, we suggest aminoglycosides (gentamicin or streptomycin with doxycycline) are associated with lower rate of relapse in brucellosis.

Highlights

Brucellosis is a zoonosis and re-emerging disease which is considered as one of the most important problems of public health in the world
It should be noted that findings the same statistical model, factors like gender, age, residence, professional contacts, complications and delay in treatment were analyzed but none of them are considered as preventive factors
Various factors of danger including demographic characteristics, clinical symptoms, some para-clinical findings and treatment regimens were studied for Malta fever relapse, among which treatment regimen was introduced as a preventive factor

Summary

Introduction

Brucellosis is a zoonosis and re-emerging disease which is considered as one of the most important problems of public health in the world. Having a thorough record of the patient which includes information like residence, job and eating foods that have highest possibility of conveying the infection is necessary and useful. Treating this disease is done with the goal of eliminating illness symptoms and decreasing the complications like arthritis, spondylitis, miscarriage and stopping the relapse of the infection (del Pozo & Solera, 2012; Smailnejad et al, 2012). Many studies refer to the factors that increase the chance of relapse, the best method for controlling the illness and relapse is still unknown. This study aimed to evaluate risk factors of relapse after treatment in patients

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