Abstract
BackgroundThe radiation-induced lung injury (RILI) in patients with advanced non-small cell lung cancer (NSCLS) is very common in clinical settings; we aimed to evaluate the risk factors of RILI in NSCLS patients, to provide insights into the treatment of NSCLS.MethodsNSCLC patients undergoing three-dimensional conformal radiotherapy (3D-CRT) in our hospital from June 1, 2018, to June 30, 2020, were included. The characteristics and treatments of RILI and non-RILI patients were analyzed. Logistic regression analyses were conducted to assess the risk factors of RILI in patients with NSCLC.ResultsA total of 126 NSCLC patients were included; the incidence of RILI in NSCLC patients was 35.71%. There were significant differences in diabetes, smoke, chronic obstructive pulmonary disease (COPD), concurrent chemotherapy, radiotherapy dose, and planning target volume (PTV) between the RILI group and the non-RILI group (all P < 0.05). Logistic regression analyses indicated that diabetes (OR 3.076, 95%CI 1.442~5.304), smoke (OR 2.745, 95%CI 1.288~4.613), COPD (OR 3.949, 95%CI 1.067~5.733), concurrent chemotherapy (OR 2.072, 95%CI 1.121~3.498), radiotherapy dose ≥ 60 Gy (OR 3.841, 95%CI 1.932~5.362), and PTV ≥ 396 (OR 1.247, 95%CI 1.107~1.746) were the independent risk factors of RILI in patients with NSCLC (all P < 0.05).ConclusionsRILI is commonly seen in NSCLS patients; early targeted measures are warranted for patients with those risk factors; future studies with larger sample sizes and different areas are needed to further elucidate the influencing factors of RILI in the treatment of NSCLS.
Highlights
The radiation-induced lung injury (RILI) in patients with advanced non-small cell lung cancer (NSCLS) is very common in clinical settings; we aimed to evaluate the risk factors of RILI in Non-small cell lung cancer (NSCLS) patients, to provide insights into the treatment of NSCLS
Local radiotherapy treatment is an important treatment of Non-small cell lung cancer (NSCLC), and radiation-induced lung injury (RILI) is a common complication of thoracic radiation therapy
The results of this study have shown that diabetes, smoke, chronic obstructive pulmonary disease (COPD), concurrent chemotherapy, radiotherapy dose ≥ 60 Gy, and planning target volume (PTV) ≥ 396 were the independent risk factors of RILI in patients with NSCLC; special attentions and early interventions are needed for NSCLC patients with those risk factors
Summary
The radiation-induced lung injury (RILI) in patients with advanced non-small cell lung cancer (NSCLS) is very common in clinical settings; we aimed to evaluate the risk factors of RILI in NSCLS patients, to provide insights into the treatment of NSCLS. Non-small cell lung cancer (NSCLC) is a common type of clinical lung cancer, which accounts for about about 40% of the total number of lung cancers [1, 2]. Local radiotherapy treatment is an important treatment of NSCLC, and radiation-induced lung injury (RILI) is a common complication of thoracic radiation therapy. Three-dimensional conformal radiotherapy (3D-CRT) refers to multiple beam irradiation technology that uses a series of different weights, different field shapes, and sizes to irradiate the target area from different directions [4,5,6]. A conformal lead that is consistent with the shape of the lesion is used to make the high-dose area consistent with the shape of the target area in three-
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
