Risk factors for pulmonary embolism in ICU patients

Abstract

Abstract Background: Pulmonary embolism (PE) is a clinical disease of pulmonary hypertension, right heart failure and pulmonary oxygen uptake dysfunction caused by obstruction of pulmonary artery blood flow caused by embolic substances. The incidence rate of acute PE (ATPE) has been increasing year by year in recent years. And ATPE has become a hot topic of common concern in the departments of severe, emergency, respiratory and heart diseases. Research and clinical practice have proved that early thrombolysis and other specific treatment can greatly improve its prognosis. However, the early diagnosis and treatment rate of ATPE is only 7%, for the lack of simple and objective diagnosis and quantitative evaluation of the degree of ATPE. Therefore, the screening of risk factors for PE in intensive care unit (ICU) patients by systematic review and meta-analysis is an important preliminary work to carry out the early diagnosis model of PE. Methods: We will retrieve eight electronic databases from their inception to May 31, 2021, which include PubMed, Cochrane Library, Excerpt Medical Database (Embase), Web of science, China Biology Medicine disc, VIP database (VIP), Wan Fang database, China National Knowledge Infrastructure. Methodological quality of all studies was assessed using the Newcastle-Ottawa scale. We will use STATA V.13.0 software and RevMan5.3 for data analysis, and risk factor effect sizes will be expressed as an odds ratio and their 95% Cl. Results: We will disseminate the findings of this systematic review and meta-analysis via publications in peer-reviewed journals. With this study, we can get the significant risk factors and risk ratio of PE in ICU patients. Conclusion: This study systematically reviewed the existing evidence and determined the risk factors for PE in ICU patients. This study provides a basis for the establishment of early warning and prediction model of PE in ICU patients.