Risk factors for proteinuria and renal insufficiency in Asian Indian patients with type 2 diabetes

Abstract

Recent evidences suggest that risk factors for albuminuria and renal insufficiency may not be the same, but data are lacking for Asian Indian patients with type 2 diabetes (T2DM). Hence, the study was planned to analyze the risk factors for proteinuria and renal insufficiency in Asian Indian patients with T2DM. In this case-control study, North Indian patients with T2DM more than or equal to 5 years were screened for proteinuria. Proteinuria included both microalbuminuria and macroalbuminuria which were defined as per standard criteria. Estimated glomerular filtration rate (eGFR) was calculated using MDRD formula, and eGFR 140 mmHg (OR 5.3), while independent risk factors for renal insufficiency were duration of diabetes >10 years (OR 1.8), systolic blood pressure >140 mmHg (OR 2.1), and triglycerides >150 mg/dl (OR 2.2). BMI >23 kg/m2 was associated with a decrease risk for both proteinuria (OR 0.4) and renal insufficiency (OR 0.3). This study reaffirms that risk factors for albuminuria and renal insufficiency are different in patients with T2DM.