Risk Factors for Potential Drug-Drug Interactions in Patients on Chronic Peritoneal Dialysis

Abstract

Plain Language SummaryIntroductionWhen people take many medications at the same time, it can be tricky. One medication might change how another one works if they are taken together, which can lead to harmful effects. This is known as potential drug-drug interactions (pDDIs), which means that two drugs might interact with each other in a way that could be harmful. This risk is even higher in patients with chronic kidney disease. Our study looked at how common pDDIs are and what factors are associated with them in patients undergoing a long-term kidney treatment called peritoneal dialysis.MethodsWe studied 140 patients who were on peritoneal dialysis and were being treated at four major hospitals in Serbia. We used a software called Lexicomp to identify pDDIs. We also used a statistical method called multiple linear regression to find out what factors might predict pDDIs.ResultsWe found that pDDIs are common, especially in patients who had just started peritoneal dialysis, had diabetes, or were taking many medications. This was particularly true for medications used to control irregular heart rhythms, known as antiarrhythmics. We also found that women had a higher risk of serious pDDIs, especially if they were taking many medications. This is important because women are more likely to experience unwanted side effects from medications.ConclusionOur study highlights the importance of checking for pDDIs, especially in patients who are at high risk. This can help avoid serious medical consequences.