Abstract
Background and Objectives: Peripheral neuropathy is a complication of diabetes mellitus (DM). Several risk factors may accelerate the development of peripheral neuropathy in DM. The objective of the current study was to determine the risk factors for development of peripheral neuropathy in patients with DM.
 Methods: The study was conducted from July 2014 to June 2015 in a large hospital of Dhaka city. A total of 150 diabetic patients of both sexes with and without peripheral neuropathy were enrolled. The investigations included interviewing on clinical history, anthropometry (height, weight, waist- and hip-circumference), blood pressure measurement, estimation of HbA1c, fasting blood glucose and lipids.
 Results: Duration of diabetes for more than 5 years was significantly (χ2=124.39, p <0.001) associated with peripheral neuropathy. Sequential logistic regression analysis revealed high BMI (> 25 Kg/m2; OR=8.8, p <0.001), HbA1c (>6.5%; OR=5.25, p<0.05) and higher total cholesterol level (> 200 mg/dl; OR=4.74, p <0.05) as the significant risk factors for peripheral neuropathy.
 Conclusion: Obesity, hyperglycemia and high total cholesterol were possible risk factors for development of diabetic peripheral neuropathy. Proper glycemic control and prevention of obesity and dyslipidemia could be helpful to avert progression to peripheral neuropathy in diabetic population.
 Ibrahim Med. Coll. J. 2019; 13(2): 40-44
Highlights
Diabetes mellitus (DM) is a clinical syndrome characterized by hyperglycemia due to relative or absolute deficiency of insulin in the body [1]
A total of 150 diabetes mellitus (DM) cases were enrolled of which Group-A had 75 DM cases without peripheral neuropathy and Group-B had 75 age matched DM
Sequential logistic regression revealed that higher Body mass index (BMI) (≥25.0 kg/m2), HbA1c (≥6.5%) and increased total cholesterol (> 200 mg/dl) were associated significantly with the occurrence of diabetic peripheral neuropathy
Summary
Diabetes mellitus (DM) is a clinical syndrome characterized by hyperglycemia due to relative or absolute deficiency of insulin in the body [1]. Peripheral neuropathy is one of the most common complications in patients with type 2 diabetes mellitus [4]. Diabetic peripheral neuropathy has been defined as the presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after exclusion of other causes. Diabetic peripheral neuropathy can affects 20%-50% of the population with diabetes [6]. A study has reported that the prevalence of diabetic peripheral neuropathy in Bangladesh is about 19.7% [7]. Peripheral neuropathy is a complication of diabetes mellitus (DM). Several risk factors may accelerate the development of peripheral neuropathy in DM.
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