Abstract
Objectives:To determine risk factors for peripheral arterial disease (PAD) in elderly patients with Type-2 diabetes mellitus.Methods:The elderly patients with Type-2 diabetes treated in the Central Hospital of Cangzhou were enrolled and divided into PAD group and non-PAD group between October 2016 and November 2019, The data of the patients including age, gender, body mass index, blood pressure, hemoglobin A1c, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride, white cell count, lymphocyte count, high-sensitivity C-reactive protein, uric acid as well as living habits and complications of Type-2 diabetes mellitus were recorded to determine the risk factors for PAD.Results:One thousand four hundred seventy six (1476) patients were enrolled, in which 465 patients were included in group of PAD, and 1011 in non-PAD group. The univariate analysis revealed that the two groups significantly differed in age (p=0.003), course of T2DM (p=0.001), hypertension (p=0.006), smoking habits (p<0.001), hyperuricemia (p<0.01), high-sensitivity C-reactive protein (p<0.01), white cell count (p<0.001), lymphocyte count (p<0.001) and diabetic neuropathy (p<0.001). In the multivariate analysis, age (OR: 1.56, 95% CI: 1.21-1.89), smoking habit (OR: 1.37, 95% CI: 1.19-1.68), hypertension (OR: 1.44, 95% CI: 1.15-1.98), diabetic neuropathy (OR: 3.55, 95% CI: 2.14-4.29), high-sensitivity C-reactive protein (OR: 1.74, 95% CI: 1.39-2.61) and hyperuricemia (OR: 2.71, 95% CI: 1.66-3.87) were significant risk factors for PAD.Conclusions:Age, smoking habit, hypertension, diabetic neuropathy, high-sensitivity C-reactive protein and hyperuricemia were independent risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus.
Highlights
Type-2 Diabetes Mellitus (T2DM), a complex chronic metabolic disorder, is steadily increasing in the world, especially in elderly population.[1]
With the coming of aging society, more elderly may suffer from T2DM and Peripheral arterial disease (PAD), which may affect the quality of life and impose a heavy burden on society adversely
PAD is defined as an ABI
Summary
Type-2 Diabetes Mellitus (T2DM), a complex chronic metabolic disorder, is steadily increasing in the world, especially in elderly population.[1]. In a study of 150 T2DM patients and 150 healthy controls, Soyoye and colleagues found PAD was associated with increasing age, male gender, obesity, and high C-reactive protein levels in people with T2DM.[6] In another study of 280 patients with T2DM, Akalu found increasing age, high HbA1c, and being cigarette smokers increase the likelihood of developing PAD.[1] the results of these studies are inconsistent, no definite conclusions are available. These studies recruited patients with different ages instead of elderly patients. The risk factors for PAD in elderly patients with T2DM are still unclear
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
