Abstract
BackgroundTo investigate the risk factors for mortality in patients with acute kidney injury requiring continuous renal replacement therapy (AKI-CRRT) after cardiac surgery.MethodsIn this retrospective study, patients who underwent AKI-CRRT after cardiac surgery in our centre from January 2015 to January 2020 were included. Univariable and multivariable analyses were performed to identify the risk factors for in-hospital mortality.ResultsA total of 412 patients were included in our study. Of these, 174 died after AKI-CRRT, and the remaining 238 were included in the survival control group. Multivariable logistic regression analysis revealed that EuroSCORE > 7 (odds ratio [OR], 3.72; 95% confidence interval [CI], 1.92–7.24; p < 0.01), intraoperative bleeding > 1 L (OR, 2.14; 95% CI, 1.19–3.86; p = 0.01) and mechanical ventilation time > 70 h (OR, 5.03; 95% CI, 2.40–10.54; p < 0.01) were independent risk factors for in-hospital mortality in patients who had undergone AKI-CRRT. Our study also found that the use of furosemide after surgery was a protective factor for such patients (odds ratio, 0.48; 95% confidence interval, 0.25–0.92; p = 0.03).ConclusionsIn summary, the mortality of patients with AKI-CRRT after cardiac surgery remains high. The EuroSCORE, intraoperative bleeding and mechanical ventilation time were independent risk factors for in-hospital mortality. Continuous application of furosemide may be associated with a better outcome.
Highlights
To investigate the risk factors for mortality in patients with acute kidney injury requiring continuous renal replacement therapy (AKI-CRRT) after cardiac surgery
Patient characteristics During the study period, 8477 patients were admitted to our centre, and the incidence of Acute kidney injury (AKI)-CRRT after cardiac surgery in our centre was approximately 4.9%, which is consistent with previous reports [12, 13]
A total of 174 patients died after AKI-CRRT, and the remaining 238 patients were included in the survival control group
Summary
To investigate the risk factors for mortality in patients with acute kidney injury requiring continuous renal replacement therapy (AKI-CRRT) after cardiac surgery. Among patients who experience AKI, 2% to 5% require continuous renal replacement therapy (CRRT) [3, 4], and their mortality rate ranges from 50 to 80% [5, 6]. The identification of risk factors in cardiac surgery patients with AKI requiring CRRT (AKI-CRRT) may help in patient stratification, resulting in more appropriate resource utilization and improving patient prognosis [5, 7]. Many studies have investigated the risk factors for AKI in patients after cardiac surgery, few studies have focused on patients with AKI-CRRT [8, 9]. The purpose of this study was to assess the risk
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