Abstract
Objective To investigate the multiple risk factors for lower extremity lymphedema in patients following treatment of common gynecologic cancers by meta-analysis for systematic analysis and comprehensive quantitative study. Methods Clinical trials published up until August 2016 were retrieved from PubMed, Embase, and the Cochrane Library. The quality of the included studies was assessed by the Newcastle-Ottawa Scale, and data analysis was performed using Stata 14.0 and RevMan 5.3. The strength of the associations between risk factors and gynecologic cancer-related lower extremity lymphedema was described as odds ratio (OR) and 95% confidence intervals (CI). Results Eighteen studies were included in the meta-analysis, and 8 relevant factors were identified. The risk factors for lower extremity lymphedema after treatment of gynecologic cancer mainly included radiotherapy (OR=2.45, 95%CI: 2.05-2.95, P=0.000), FIGO stage (OR=2.29, 95%CI: 1.66-3.14, P=0.000), and pelvic lymph node dissection (OR=2.00, 95%CI: 1.02-3.91, P=0.040). Conclusions Radiotherapy, FIGO stage, and pelvic lymph node dissection are the main risk factors for lower extremity lymphedema after treatment of gynecologic cancers. Key words: Gynaecological neoplasms; Lower extremity lymphedema; Risk factors
Published Version
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