Abstract
BackgroundAlthough fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe & North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence.ResultsMedian patient follow up was 61 months, 5 year overall survival (OS) rate was 94.2% (95% CI 93–95.3). We found that 108 out of 2,754 (5.3%) patients had loco-regional recurrence. The 2-year loco-regional control was 98% (95% CI 97.3–98.7) and 5-year was 94% (95% CI 92.6–95.4). Univariate analysis showed a correlation between recurrence and being <50 year-old, positive surgical margins, advanced stage, subtype, and presence of LVI and omission of adjuvant radiotherapy. Only the absence of adjuvant RT was predictor of locoregional recurrence in multivariable (p < 0.001).ConclusionsOur study population presents high local control of BC. Age, surgical margins, stage, molecular subtype and absence of adjuvant radiotherapy were associated with loco-regional recurrence. Prospective trials and long-term follow up are required in order to confirm these results.Materials and MethodsWe analyzed medical records from 2,201 BC patients at the Pontificia Universidad Católica de Chile from 1997 to 2016. Collected data included: age at diagnosis, tumor size, axillary involvement, molecular subtype, margin status, histological grade, lympho-vascular invasion (LVI) and ipsilateral recurrence.
Highlights
Mastectomy has been both the most common surgical treatment for stage I/II breast cancer (BC) and the preferred treatment for loco-regional disease
We found that 108 out of 2,754 (5.3%) patients had loco-regional recurrence
Univariate analysis showed a correlation between recurrence and being
Summary
Mastectomy has been both the most common surgical treatment for stage I/II breast cancer (BC) and the preferred treatment for loco-regional disease. Treatments may consist in a combination of breast conserving surgery (BCS) plus radiotherapy (RT). Several prospective randomized clinical trials have demonstrated that this combination approach provides local control and patient survival rates equivalent to those observed with mastectomy [1]. About 17% of patients treated with BCS plus RT develop ipsilateral breast tumor recurrence (IBTR) within 20 years of treatment [2]. Patients that developed IBTR or loco-regional recurrence (LRR) have a significantly poorer prognosis [4]. Loco-regional recurrence in breast cancer (BC) has major consequences for the patient. We performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence
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