Risk factors for development of succinylcholine-induced postoperative myalgia

Abstract

Objective To determine the risk factors for development of succinylcholine-induced postoperative myalgia. Methods One hundred and fifty-five patients, aged 18-64 yr, of ASA physical status Ⅰ or Ⅱ, with body mass index of 20-30 kg/m2, scheduled for elective craniofacial surgery, were included in the study.Total intravenous anesthesia with propofol or combined intravenous-inhalational anesthesia with sevoflurane was performed during surgery.The patients were divided into 2 groups according to whether or not myalgia occurred within 24 h after surgery: myalgia group and non-myalgia group.Factors including gender, age, body weight, duration of surgery, method of anesthesia, dose of succinylcholine, preinjection of lidocaine or nondepolarizing muscular relaxants during induction of anesthesia, use of hormone(dexamethasone or methylprednisolone)and nonsteroidal analgesics(parecoxib sodium)during surgery, and consumption of fentanyl were recorded.The risk factors of which P values were less than 0.05 would enter the multivariate logistic regression analysis to stratify the risk factors for development of succinylcholine-induced postoperative myalgia. Results Forty-one patients developed postoperative myalgia, and the incidence of myalgia was 27.2%.The results of logistic analysis indicated that succinylcholine <1.5 mg/kg and no preinjection of lidocaine were closely correlated with the development of postoperative myalgia induced by succinylcholine. Conclusion Succinylcholine<1.5 mg/kg and no preinjection of lidocaine are the risk factors for development of succinylcholine-induced postoperative myalgia in the patients. Key words: Succinylcholine; Fibromyalgia; Postoperative complications; Risk factors