Abstract
We conducted a retrospective study aiming to assess the risk, and associated risk factors, of developing subsequent skin cancers after having a first diagnosis of skin cancer. We included all patients with biopsy-proven skin cancer attending a dermatology clinic between July 2007 and July 2017. We assessed the frequency of new skin cancers, as well as potential demographic and clinical factors significantly associated with occurrence of such neoplasms, that were identified by means of a survival analysis. We analyzed 969 patients with a total of 1584 skin neoplasms (1122 basal cell carcinomas (BCC), 310 squamous cell carcinomas (SCC), 143 melanomas and 9 other neoplasms). 165 patients (17.0%) developed subsequent skin neoplasms. Factors identified in multivariable models to be significantly associated with development of new skin cancers included older age (adjusted HR = 1.04 per year; 95%CI = 1.02–1.05; p < 0.001), and presence of synchronous neoplasms (adjusted HR = 2.25; 95%CI = 1.61–3.14; p < 0.001). Having a history of a BCC was significantly associated with development of new BCC (adjusted HR = 1.63; 95%CI = 1.05–2.54; p = 0.030), while having a previous SCC was associated with occurrence of subsequent SCC (adjusted HR = 3.60; 95%CI = 1.93–6.72; p < 0.001). These findings point to the importance of careful follow-up (e.g., skin self-examination and full body examination) of skin cancer patients.
Highlights
The skin is the most frequent location of primary malignant neoplasms[1,2,3]
We assessed 969 different patients with a total of 1584 skin neoplasms; 675 patients had a single skin neoplasm, while 294 individuals had more than one skin cancer
Advanced age and detection of synchronous neoplasms at first diagnosis were identified as risk factors for the development of new skin neoplasms
Summary
The skin is the most frequent location of primary malignant neoplasms[1,2,3]. skin cancer incidence is increasing worldwide[4,5,6]. It is known that when a patient is diagnosed for the first time with skin cancer, there is an increased risk of developing subsequent skin neoplasms[10,11,12]. This increased risk has been insufficiently quantified and associated epidemiological factors have not been properly identified. This study aims to evaluate the risk of developing a subsequent skin neoplasm after having a first diagnosis of skin cancer, as well as to identify potential factors associated with an increased risk of new neoplasms
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