Abstract
Background/aimWe aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in a young population with stable angina pectoris (SAP).Materials and methodsA total of 571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain and referred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis of ≥70%, and the control group consisted of 208 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors of these two groups in terms of the presence of CAD.ResultsPrevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabetes were similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyltransferase, hemoglobin, and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels, older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors for the presence of CAD in young patients.ConclusionContrary to studies performed in the elderly, traditional and nontraditional risk factors could not exactly predict the presence of CAD in a young population with SAP.
Highlights
Coronary artery disease (CAD) is a major cause of death worldwide [1]
There is a growing interest in the identification and treatment of risk factors for CAD in young patients in order to decrease the incidence of CAD through risk modification and increase the quality of life through treatment [4,5]
Traditional and nontraditional CAD risk factors are well defined for elderly patients with acute coronary syndrome (ACS), they are not fully clarified in younger people with stable angina pectoris (SAP)
Summary
Coronary artery disease (CAD) is a major cause of death worldwide [1] It has commonly been associated with aging; the frequency of CAD in young individuals has been increasing in recent years [2,3]. In order to provide earlier and better diagnosis of CAD in young adults, novel risk factors and markers have been evaluated in the literature [6,7,8]. These studies included specific cohorts, such as ACS [6,7,8,9].
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