Abstract
Band keratopathy (BK) is a common complication in aphakic eyes with silicone oil tamponade for open-globe injury (OGI), characterized by the grayish-white opacities in the cornea, resulting in a significantly decreased vision when extending to the visual axis. To identify the risk factors for BK in aphakic eyes following vitreoretinal surgical treatment with silicone oil tamponade for OGIs, we performed a multicenter case-control study. The incidence of BK was 28% (28/100 eyes). The multivariate binary logistic regression revealed the silicone oil retention time (SORT) ≥6 months and zone III injury were significant risk factors for BK. From the hierarchical interaction, SORT ≥6 months had a significant risk for BK in eyes with rupture, aniridia, and zone III injury, while zone III injury had a significant risk for BK in eyes with rupture, incomplete/complete iris, and SORT ≥6 months. By using restricted cubic splines with three knots at the 25th, 50th, and 75th centiles to model the association of SORT with BK, we also found a marked increase in the risk for BK at ≥10 months and a slow increase after 6 months, but almost stable within 4–6 months.
Highlights
Open globe injury (OGI) is a common cause of unilateral visual impairment and blindness worldwide [1, 2]
For patients with complicated Retinal detachment (RD) in OGI, silicone oil tamponade is necessary, even in the long term in some patients. It is well-known that silicone oil tamponade has some complications such as band keratopathy (BK), which is characterized by the deposition of grayish-white opacities in the superficial layers of the cornea, resulting in a significantly decreased vision when the opacities extend to the visual axis
After adjusting for age and other selected variables, the results showed that age (OR = 1.04; 95% confidence intervals (CIs): 1.00– 1.08, P = 0.08) was close to a borderline, and silicone oil retention time (SORT) (OR = 1.32; 95% CI: 1.06–1.21, P = 0.001) and zone of injury (OR = 6.88; 95% CI: 1.94–24.44, P = 0.001) remained as independent risk factors for BK
Summary
Open globe injury (OGI) is a common cause of unilateral visual impairment and blindness worldwide [1, 2]. Severe and complicated ocular trauma can break the iris-lens barrier and affect both the anterior and posterior segments, leading to an enormous variety of anterior segment injuries of the eye, including open corneal trauma, complete or incomplete iris defect, Risk Factors for Band Keratopathy traumatic cataract, ciliary body detachment, and cyclodialysis [3, 4]. For patients with complicated RD in OGI, silicone oil tamponade is necessary, even in the long term in some patients. It is well-known that silicone oil tamponade has some complications such as band keratopathy (BK), which is characterized by the deposition of grayish-white opacities in the superficial layers of the cornea, resulting in a significantly decreased vision when the opacities extend to the visual axis. Patients with BK may suffer from eye irritation and pain [6]
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