Abstract
The prevalence and risk factors for autism spectrum disorders (ASD) in a cohort of 103 patients with tuberous sclerosis complex (TSC) were determined in a study at the Massachusetts General Hospital, Boston, MA.
Highlights
Missed signs of TSC, and presenting symptoms and signs according to age group are reported from the Massachusetts General Hospital study of 243 patients with TSC (Staley BA et al Pediatrics Jan 2011;127:ell7-el25)
Frontal/prefrontal lobe growth retardation is reported in children with BCECTS complicated by cognitive impairments and behavioral problems compared with BCECTS patients without neuropsychiatric deficits. (Kanemura H et al Brain Dev Feb 2011;33:106-113)
Impaired frontal lobe growth is associated with frequent seizures and spike/wave discharges and neuropsychological problems
Summary
Missed signs of TSC, and presenting symptoms and signs according to age group are reported from the Massachusetts General Hospital study of 243 patients with TSC (Staley BA et al Pediatrics Jan 2011;127:ell7-el25). The present report shows an increased risk of attention disorder in children with AED-resistant seizures and having more frequent epileptiform discharges in the EEG. Frontal/prefrontal lobe growth retardation is reported in children with BCECTS complicated by cognitive impairments and behavioral problems compared with BCECTS patients without neuropsychiatric deficits.
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