Risk factors for acute lung injury in living donor liver transplant recipients with biliary atresia in children

Abstract

Objective To explore the risk factors of acute lung injury in pediatric living donor liver transplant recipients with biliary atresia (BA). Methods The clinical data were retrospectively reviewed for 112 BA children undergoing living donor liver transplantation from May 2012 to March 2016.And the risk factors of acute lung injury after living-donor liver transplantation were analyzed. Results Twenty-three children (20.5%) developed acute lung injury after transplantation.Univariate analysis showed that acute lung injury was associated with age (P=0.010), pretransplant albumin (P=0.012), pretransplant total bilirubin (P=0.001), pretransplant creatinine (P<0.001) and postoperative bilirubin peak (P=0.035). And multivariate analysis indicated that pretransplant albumin (P=0.006, OR=0.813, confidence interval 0.701 to 0.942), pretransplant total bilirubin (P=0.001, OR=1.010, confidence interval 1.004 to 1.016) and pretransplant creatinine (P=0.001, OR=1.237, confidence interval 1.104 to 1.387) were risk factors for acute lung injury after transplantation. Conclusions Pretransplant albumin, pretransplant total bilirubin and pretransplant creatinine are prognostic risk factors for acute lung injury after living-donor liver transplantation in children. Key words: Liver transplantation; Acute lung injury; Child; Retrospective studies; Biliary atresia