Abstract
SummaryThe vestibulocochlear nerve schwannoma (VS) is a benign tumor that stems from the edge of the Schwann's sheath. It is considered the most frequent intracranial benign tumor, of low lethality rate and unknown etiology.Aimto identify risk factors associated with VS.Study designsystematic review.Methodselectronic search of studies using the following key words: “risk”, “schwannoma”, “vestibular”, “neuroma” and “acoustic”. All original articles on epidemiological studies published in Portuguese, English or Spanish describing measures of association were included.Resultstwenty case-control studies were found, most of them published in the United States. The analysis of those studies shows educational level, household income, occupation, exposure to ionizing radiation and noise, allergic diseases as well as the use of both cellular and cordless phones as risk factors for the VS.Conclusionmethodological limitations and lack of precision in the findings impose limits to definitive conclusions concerning those risk factors. The current study contributes with information which can subsidize decisions related to the methodology to be used, having in mind new investigations on risk factors for VS. Therefore, it is of great help for knowledge improvement in this field.
Highlights
The vestibular nerve schwannoma (VS) is a benign tumor that stems from the Schwann’s sheath of one of the vestibular nerves
We included only original epidemiology research papers published in Portuguese, Spanish or English, from 1966 to November of 2006, which investigated risk factors associated with VS, and which reported some measure of association
We found 265 papers, from which we selected 20
Summary
The vestibular nerve schwannoma (VS) is a benign tumor that stems from the Schwann’s sheath of one of the vestibular nerves. It is considered the most frequent among intracranial benign tumors - representing 90% of the ponto-cerebelar angle tumors and from 8 to 10% of all the cranial tumors. It is unilateral in about 95% of the cases. It is not associated to any specific race[1,4,5] and it is more common in women at a 3:2 ratio. Its unilateral manifestation seems to be more common in men[6]
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