Abstract
Aim: To evaluate health-related quality of life (HRQoL) of chronic hepatitis B (CHB) and hepatitis B virus (HBV) related cirrhosis patients and analyzed specific differences in all dimensions of HRQoL.Methods: A total of 349 patients met selection criteria were enrolled. The 36-Item Short-Form Health Survey was adopted.Results: Results showed that the physiological HRQoL of the cirrhotic group was significantly lower than that of the non-cirrhotic group (P = 0.003), the psychological HRQoL was also lower (P = 0.006). HRQoL was significantly negatively correlated with liver stiffness (P = 0.001). We further evaluated the risk factors associated with poor HRQoL in HBV-related cirrhosis patients. Results showed that positive HBV DNA viral load (OR = 6.296, P = 0.041) and HCC family history (OR = 36.211, P = 0.001) were independent factors associated with HRQoL in HBV-related cirrhosis. For better risk stratification of patients, multivariable analyses were conducted to explore the independent factors that affected specific physiological and psychological HRQoL. In specific physiological HRQoL, results show that marital status (OR = 9.971, P = 0.034), positive HBV DNA viral load (OR = 6.202, P = 0.042) and antiviral drugs (OR = 0.45, P = 0.031) were independent factors associated with physiological HRQoL in cirrhosis patients. In psychological HRQoL, only HCC family history was independent risk factors associated with psychological HRQoL (OR = 42.684, P = 0.002).Conclusion: We found that the impaired HRQoL dimensions of HBV related cirrhosis patients differ between the various subpopulations. According to our results, risk stratification, medical decision making and personalizing interventions could be made.
Highlights
Hepatitis B virus (HBV) infection is a serious public health burden worldwide (Sarin et al, 2016)
Patients were excluded if they had hepatocellular carcinoma (HCC); co-infections with hepatitis C virus, hepatitis D virus, or HIV; any medical evidences of autoimmune hepatitis; heavy alcohol abuse; were pregnant; Demographic Data in Chronic Hepatitis B Patients With or Without Cirrhosis
In specific physiological health-related quality of life (HRQoL) (Table 3), results show that marital status (OR = 9.971, P = 0.034), positive HBV DNA viral load (OR = 6.202, P = 0.042) and antiviral drugs (OR = 0.45, P = 0.031) were independent factors associated with physiological HRQoL in cirrhosis patients
Summary
Hepatitis B virus (HBV) infection is a serious public health burden worldwide (Sarin et al, 2016). Epidemiological research has shown that approximately 240 million patients have a diagnosed chronic HBV infection (Lok and McMahon, 2009; Sarin et al, 2016). Anti-HBV treatment is the most fundamental and important treatment for chronic hepatitis B (CHB) (European Association for the Study of the Liver [EASL], 2017). Drugs that are licensed for anti-HBV treatment include interferon and nucleoside analogs (NAs). NAs can prevent the progression of hepatic impairment in CHB patients by inhibiting HBV replication, they cannot directly clear the cccDNA of HBV. Most patients with CHB who are treated with NAs need to receive therapy for a very long time
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