Abstract
Dengue fever is an increasing health problem in tropical and subtropical regions. During 2010 in Medellin, the younger population presented a particularly high dengue incidence rate. This study estimated dengue virus (DENV) transmission in schoolchildren (aged 5–19 years) in Medellin from 2010 to 2012. A longitudinal serological survey (IgG) and spatial analysis were conducted to determine the distribution of DENV seroprevalence. A total of 4,385 schoolchildren participated for at least one year. Dengue seroprevalence significantly increased during the studied period (53.8% to 64.6%; p < 0.001). A significantly higher seroconversion rate was observed in 2010-2011 (16.8%) compared to 2011-2012 (7.8%). Multivariate regression analysis showed that the main factor associated with the seroprevalence was the aging. Furthermore, in 2010, patients with high socioeconomic status presented a lower risk. Predominant multitypic and DENV4 monotypic antibody responses were demonstrated. Geostatistical analysis evidenced a temporal clustering distribution of DENV seroprevalence in 2010. Population density and Ae. aegypti House Index were significantly correlated with the observed pattern. This study revealed high DENV transmission in schoolchildren determined as “sentinel population.” High DENV risk was found in districts with combined poorly socioeconomic conditions and densest human and mosquito populations. These findings may allow to target population for effective prevention and vaccination campaigns.
Highlights
Dengue fever is an acute disease caused by dengue virus (DENV), an arbovirus that belongs to the Flaviviridae family, Flavivirus genus
All socioeconomic statuses (SESs) were represented, but low and medium SESs prevailed. rough 2012, there were not scholars belonging to a high SES (Table 1)
In the present study, using a representative sample of schoolchildren population from districts of the urban area of Medellin, we combined serologic and sociodemographic data and entomologic and geospatial information to better understand DENV transmission patterns. is study is one of the few studies in the country [26] to describe the hidden scale of DENV infection, during 2010, a year with the largest outbreak reported in the region over the last decade. e rst principal nding of this study is that dengue IgG seroprevalence increased signi cantly along with the study progress in schoolchildren population
Summary
Dengue fever is an acute disease caused by dengue virus (DENV), an arbovirus that belongs to the Flaviviridae family, Flavivirus genus. DENV is the most prevalent arbovirus in humans, and it is considered a major public health problem in the tropical and subtropical regions [2]. Dengue fever has a vast clinical spectrum from asymptomatic, subclinical, undifferentiated febrile syndrome to severe disease [3]. In 2009, the World Health Organization (WHO) proposed to categorize the disease into dengue and severe dengue [2]. Severe dengue can be caused by any serotype [4] and is characterized by plasma leakage, bleeding, and/or organ injuries [5]. During the decade 2000–2010, Latin America and the Caribbean region reported high numbers of dengue cases and additional transmission of all four
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Canadian Journal of Infectious Diseases and Medical Microbiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
