Risk Factors Associated with Cervical Cancer: A Matched Case-control Study

Abstract

Background: One of the most effective ways to prevent cervical cancer is to identify the risk factors for the disease. Objective: The purpose of this research was to determine the risk factors for cervical cancer in women in Iran. Methods: This was a matched case-control study. 105 participants (35 patients with cervical cancer and 70 healthy women) were selected from the registered patients and women attending a women’s specialized hospital in Hamadan, Iran. One case was matched to 2 controls by age (±3 years). Demographic and clinical data were collected using a semi-structured questionnaire. Conditional multivariate logistic regression model and STATA 11 software were used for data analysis. Results: The mean age of women in the case and control group were 58.02(12.32) and 58.11(12.25) years (P = 0.486), respectively. Patients had lower education levels (P = 0.037), lower economic status (P˂0.001), and lower spouse education levels (P = 0.009). The results showed OCP users were 8.79 times more likely to develop cervical cancer than women who do not use OCP (P = 0.007), and the probability of cervical cancer in women increased by 8.33 times (<0.001) with decreasing each level of socio-economic status. Conclusion: The results of the present study showed low economic status, and a history of using oral contraceptive pills are risk factors for cervical cancer.