Risk factors and prognosis analysis of the patients with solid tumors complicated with disseminated intravascular coagulation

Abstract

Objective To investigate the risk factors and prognosis of the patients with malignant solid tumors complicated with the disseminated intravascular coagulation (DIC). Methods The clinical data of 54 malignant solid tumors patients complicated with DIC in Shanxi Provincial People's Hospital from January 2004 to December 2014 were analyzed retrospectively, which were compared with the malignant tumor patients without DIC. Multivariate logistic regression analysis was used to explore the risk factors of solid tumor complicated with DIC, and the effect of concurrent DIC on the prognosis of patients was analyzed. Results Multiple factor analysis showed that advanced tumor (OR = 0.252, P = 0.019), concurrent hypoproteinemia (OR = 0.119, P = 0.005), concurrent infection (OR = 0.122, P = 0.003) were the independent risk factors of the malignant solid tumor patients complicated with DIC. The case fatality rate of the patients with DIC was 85.2% (46/54), which was higher than that of the control group (7.4%, 4/54), and the difference was statistically significant (χ 2 = 65.69, P < 0.001). Conclusion Early detection of malignant solid tumors, positive correction of hypoproteinemia, and the effective control of infection as soon as possible can help to prevent the occurrence of DIC and reduce the death caused by DIC. Key words: Neoplasms; Disseminated intravascular coagulation; Risk factors; Prognosis