Abstract
Objective To investigate risk factors thatareassociated with heterotopic pregnancy (HP) followingin vitro fertilization-embryo transfer (IVF-ET) and to review surgical management and clinical outcomes of patients with heterotopic pregnancy. Methods Clinical data of HP patients in Reproduction Center of the Third Affiliated Hospital of Zhengzhou University from January 2008 to December 2016 were retrospectively analyzed.1) There were 29 HP patients (HP group), and totally87 additional patients were randomly selected as controls from the IVF registry database. Baseline characteristics, reproductive and obstetric outcomes were compared between HP group and control group.2)We retrospectively analyzed 19 HP patients with viable intrauterine pregnancy surgical management, and clinical outcomes according to medical records and follow-up telephone interviews. Results 1)HP group had more tubal factor infertility (68.97%) and more embryos transfer (100.00%) compared with control group (44.83%, 82.76%) (P=0.024,P=0.038). Logistic regression analysis showed that multiple embryo transfer and tubal factor infertility were identified as the independent factors of HP. The early abortion rate in HP group (34.48%) was higher than that in control group (10.34%) (P=0.006). The live birth rate in HP group (51.72%)was lower than that in control group (83.91%) (P=0.001).2)The operation time and mass size affected survival rate of intrauterine pregnancy with statistically significant differences (P=0.023,P=0.004). Conclusion Factors such as multiple embryo transfer and tubal factor infertility increase the risk of HP. The related factors affecting the survival rate of intrauterine pregnancy is operation time and mass size. With increased awareness of HP in patients who have undergone IVF-ET, early diagnosis and appropriate surgical treatment may lead to a favorable prognosis. Key words: Fertilizationin vitro; Embryo transfer; Pregnancy, heterotopic; Pregnancy outcome; Risk factors
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