Risk factors and prediction equation linked to early pulmonary metastasis of hepatocellular carcinoma after curative hepatic resection

Abstract

Objective To investigate the risk factors and the prediction equation linked to early pulmonary metastasis of hepatocellular carcinoma after curative hepatic resection.Methods A series of 400 hepatocelluar carcinoma patients who received radical operation were investigated retrospectively. Single factor analysis and multivariate logistic regression analysis were performed to analyze the relevant clinical and pathological indicators,including sex,ages,tumor diameter,the level of alpha fetal protein (AFP),hepatitis B virus (HBV) infection,number of tumors,hepatic cirrhosis,tumor envelop,tumor thrombus,and pathological classification,etc.Results The ratio of pulmonary metastasis one year postoperation was 8.0％ (32/400).The indicators,including the tumor diameter,the level of AFP,and tumor thrombus were different significantly between pulmonary metastasis group and non-pulmonary metastasis group.The multivariate logistic regression analysis indicated that the independent prognostic factors of pulmonary metastasis of hepatocelluar carcinoma one year after curative hepatic resection were the tumor diameter and tumor thrombus.The prediction equation indicated that the predicted ratio of pulmonary metastasis was from 1.14％ to 27.23％.Conclusion The independent prognostic factors of pulmonary metastasis of hepatocelluar carcinoma one year after curative hepatic resection were the tumor diameter and tumor thrombus. Key words: Carcinoma, hepatocelluar; Pulmonary metastasis; Prediction