Abstract
Introduction: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. Identification of high-risk patients displays an important issue for clinicians. Beside bacterial infections some studies suggested a strong influence of fungal infections on survival in PSC patients.
Highlights
Candidiasis is commonly observed in patients with primary sclerosing cholangitis (PSC), but the clinical risk factors associated with its presence have not been fully investigated
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and stricture formation of the intra- and extrahepatic biliary system, which progresses to liver cirrhosis in the majority of cases [1,2,3]
Patients and study design This study was designed to analyse clinical risk factors that are associated with biliary candidiasis and to assess how the outcome is influenced by the presence of transient and persistent biliary candidiasis
Summary
Candidiasis is commonly observed in patients with primary sclerosing cholangitis (PSC), but the clinical risk factors associated with its presence have not been fully investigated. We aimed to analyse the incidence, risk factors, and transplantation-free survival in primary sclerosing cholangitis (PSC) patients with persistent biliary candidiasis. There is a strong association with inflammatory bowel disease (IBD) in about 75% of patients, and a clear male predominance [4]. Therapeutic options for this condition are limited, and the data regarding the survival benefits of ursodeoxycholic acid treatment are conflicting [5,6,7,8], it remains the most frequently used therapeutic agent. Recent studies highlighted the influence of numerous genetic risk factors [11,12,13], and it is well accepted that immunological and environmental factors, such as transmission of bacterial pathogens from the gut due to increased permeability of the portal venous system, are involved [14,15,16]
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