Abstract
The aim of the study was to evaluate the risk factors and the incidence of comorbidity in patients with coronary heart disease, depending on the presence of atrial fibrillation. Materials and methods of research: a retrospective analysis of 222 stories of illnesses of patients with coronary heart disease who undergo inpatient treatment, aged from 39 to 88 years, has been conducted. Depending on the presence of atrial fibrillation, all patients were divided into 2 groups: group 1 (main) - patients with ischemic heart disease with atrial fibrillation (n = 105), group 2 (comparison) - patients with ischemic heart disease without atrial fibrillation (n = 117). Results. In the group of patients without AF, the proportion of persons with inherited exacerbations of IHD was 64.29 %, while in the main group - 25.0 %, the differences did not reach the statistically significant level, but this relationship is confirmed by the results of the rank correlation analysis - between the presence AP and heredity revealed a significant weak feedback - c=-0.21 (p<0.05). The diseases that were observed in the examined patients with coronary artery disease present acute violation of cerebral circulation, angina pectoris, acute myocardial infarction, hypertension, diabetes, pathology of the kidneys and the thyroid gland, diastolic dysfunction and obesity. The groups differed in the proportion of patients with stroke - in the group with AF, it was significantly (p=0.002) higher - 23.81 %, in compare to 8.55 % in the comparison group. Conclusions: The presence of atrial fibrillation in patients with coronary heart disease is associated with a high degree of comorbidity. First of all, with the combination of IHD and atrial fibrillation, a high incidence of hypertension, diabetes mellitus, obesity, acute cerebrovascular disorder, kidney disease and thyroid gland is established.
Highlights
At present, atrial fibrillation (AF) is one of the most common forms of arrhythmias, which often leads to acute cerebrovascular disruption and has a negative social significance [1, 2]
To evaluate the function of the kidneys were performed the determination of creatinine and the calculation of glomerular filtration rate (GFR) according to the MDRD formula [10] according to the recommendations of the American National Federation of Nephrology [5, 10]
Analysis on the homogeneity of the study groups showed that there were no significant differences in the distribution of patients in groups depending on sex, anthropometric indicators, risk factors (p>0.05), indicating their comparability and allows comparisons of other parameters
Summary
Atrial fibrillation (AF) is one of the most common forms of arrhythmias, which often leads to acute cerebrovascular disruption and has a negative social significance [1, 2]. Every fifth case of stroke is due to the presence of atrial fibrillation [3, 4]. In this case, ischemic strokes in this type of arrhythmias often have fatal consequences, and those surviving patients have consequences with severe disability [5]. Ischemic strokes in this type of arrhythmias often have fatal consequences, and those surviving patients have consequences with severe disability [5] It is known, that spread of comorbidity is connected with age [6]. The study of risk factors and comorbidity in patients with atrial fibrillation of non-valvular genesis requires a detailed analysis, since it has clinical significance for the prevention and treatment of this category of patients
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