Risk factors and clinical impact associated with infections caused by different types of carbapenem-resistant Klebsiella pneumoniae in China: A clinical study from 2014 to 2017

Abstract

We read with great interest on a recent study by Tao Lou and colleagues entitled “Risk factors for infection and mortality caused by carbapenem-resistant Klebsiella pneumoniae: A large multicentre case-control and cohort study” in this journal. 1 Lou T. Du X. Zhang P. Shi Q. Han X. Lan P. et al. Risk factors for infection and mortality caused by carbapenem-resistant Klebsiella pneumoniae: a large multicentre case–control and cohort study. J Infect. 2022; Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar Data from this study showed a very high clinical mortality rate caused by carbapenem-resistant K. pneumoniae (CRKP) infections, reaching 24.2% for the 28-day crude mortality and over 45% for blood-stream infections. We believe that CRKP strains in this study included the newly discovered carbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP). 2 Gu D. Dong N. Zheng Z. Lin D. Huang M. Wang L. et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018; 18: 37-46 Abstract Full Text Full Text PDF PubMed Scopus (407) Google Scholar It is interesting and important to compare the clinical mortality caused by CRKP and CR-HvKP strains. We have conducted a study to compare the clinical risk factors involved in clinical infections caused by CRKP and CR-HvKP strains, which will provide additional insights into current study.