Risk factor of osteonecrosis of the femoral head in patients with systemic lupus erythematosus

Abstract

Objective To investigate the risk factor of osteonecrosis of the femoral head (ONFH)in patients with systemic lupus erythematosus (SLE).Methods 376 patients with SLE in our hospital were enrolled in the present study.The retrospective analysis was made to investigate the risk factor of ONFH on the pathological and follow-up data.Results The incidence of ONFH in 376 SLE patients was 7.18%.Oral ulcer,Renault's phenomenon,vasculitis,osteoporosis,TC,TG,accumulated dosage of hormone and hormone intensive therapy were the risk factors of ONFH.Conclusion The incidence of ONFH in patients with SLE is relatively high,and the risk factors include Renault' s phenomenon,vasculitis,osteoporosis,TC,TG and usage of immunosuppresive treatment,especially the hormone intensive therapy with large doses. Key words: Lupus erythematosus; Femur head necrosis; Risk factor