Abstract
BackgroundPediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP.MethodsCP patients admitted to our center from January 2000 to December 2013 were enrolled. Patients were assigned to the pediatric (< 18 years old) and adult group according to their age at onset of CP. Cumulative rates of steatorrhea in both groups were calculated. Risk factors for both groups were identified, respectively.ResultsThe median follow-up duration for the whole cohort was 7.6 years. In a total of 2153 patients, 13.5% of them were pediatrics. The mean age at the onset and the diagnosis of CP in pediatrics were 11.622 and 19.727, respectively. Steatorrhea was detected in 46 patients (46/291, 15.8%) in the pediatric group and in 447 patients (447/1862, 24.0%) in the adult group. Age at the onset of CP (hazard ratio [HR], 1.121), diabetes mellitus (DM, HR, 51.140), and severe acute pancreatitis (SAP, HR, 13.946) was identified risk factor for steatorrhea in the pediatric group.ConclusionsAge at the onset of CP, DM and SAP were identified risk factors for the development of steatorrhea in pediatric CP patients. The high-risk populations were suggested to be followed up closely. They may benefit from a full adequate pancreatic exocrine replacement therapy.
Highlights
Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea
After the exclusion of 134 patients, including 10 patients diagnosed with grooved pancreatitis (GP), 108 patients diagnosed with autoimmune pancreatitis (AIP), and 16 patients diagnosed with pancreatic cancer within 2 years after the diagnosis of CP, a cohort of 2153 patients with CP was established
The risk of developing steatorrhea was significantly higher in pediatric patients with a history of severe acute pancreatitis (SAP) before the diagnosis of CP (Hazard ratio [HR], 13.946, 95% Confidence interval (CI), 1.442– 134.909)
Summary
Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. Chronic pancreatitis (CP) is a rare disease in children. Recent studies have estimated that the incidence of CP in children is approximately 0.5 per 100,000 per year [1,2,3]. The essence of this disease is the destruction of the organ’s parenchyma by a progressive inflammation process [4]. Pediatric patients with CP always suffer from the severe pain and progressive loss of both exocrine and endocrine function. The irreversible damage of in CP patients, a significant proportion of PEI did not show dominant steatorrhea. Functional testing directly for PEI is difficult in clinical practice
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
