Abstract
Background. The aim of this study was determine the prognostic value of medical, biological and socio-hygienic factors in the formation of H.pylori infection in children.Methods. 283 children aged 7 to 17 years with chronic gastroduodenal pathology in the acute stage were observed. Patients were divided into two groups depending on the presence of H.pylori. The main group included 224 (79.1 %) patients with H.pylori-positive status, control group included 59 (20.9 %) patients who had H.pylori-negative status.Results. Тhe article presents the basic medical and biological and socio-hygienic risk factors in the formation of H. pylori infection in children. With the help of mathematical program processed 145 parameters, including biomedical, social and health indicators of child development in the prenatal and postnatal periods, the clinical manifestations of chronic gastroduodenal pathology, which allowed identifying the main bio-medical and socio-hygienic risk factors of high significance (relative risk > 2.0). We have found out an association of genetic risk factors in the development of H.pylori infection in children in accordance with polymorphisms ASP299GLY of gene Toll-like receptor 4. We have determined the basic clinical and endoscopic features of chronic gastroduodenal pathology in children with H.pylori-positive status and their informational value.
Highlights
Helicobacter pylori (H.pylori) is conceded as the causative agent of one of the most common chronic bacterial infections of human worldwide
The high prevalence of H.pylori is almost always correlated with low socio-economic status of the population [4, 7]
H.pylori infection causes an inflammatory response almost at all infected individuals, but the severity of inflammation depends on the interaction of many factors, first of all, such as the virulence of the bacteria, bio-medical and socio-hygienic factors of an infected person’s organism, which predetermine the formation of H.pylori infection in children [2, 6]
Summary
Helicobacter pylori (H.pylori) is conceded as the causative agent of one of the most common chronic bacterial infections of human worldwide. It is proved that at the present time about half of the world’s population is infected by H.pylori, at the same time, the prevalence of H.pylori is different in different countries. The high prevalence of H.pylori is almost always correlated with low socio-economic status of the population [4, 7]. There were no large epidemiological studies examining the infection of the population of Ukraine by H.pylori carried out. H.pylori infection causes an inflammatory response almost at all infected individuals, but the severity of inflammation depends on the interaction of many factors, first of all, such as the virulence of the bacteria, bio-medical and socio-hygienic factors of an infected person’s organism, which predetermine the formation of H.pylori infection in children [2, 6]
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