Risk factor compositions of nonalcoholic fatty liver disease change with body mass index in males and females.

Long Wang,Jinghui Guo,Jianping Lu

doi:10.18632/oncotarget.9691

Long Wang, Jinghui Guo + Show 1 more

Open Access

https://doi.org/10.18632/oncotarget.9691

Copy DOI

Journal: Oncotarget	Publication Date: May 30, 2016
Citations: 56	License type: cc-by

Affiliation: Shanghai Jiao Tong University

Abstract

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and correlated with obesity. To evaluate the role of body mass index (BMI) and gender difference in NAFLD, 8817 general adult subjects underwent physical examinations and were divided into four groups: underweight, normal, overweight and obese. The risk factor compositions for NAFLD were evaluated in each group by gender. The percentage of subjects with NAFLD increased sharply from 0.4% in the underweight group up to 81.9 % in the obese group. BMI stratification showed distinct risk factor compositions associated with NAFLD in males and females according to BMI and improved the performance of NAFLD prediction models in each group. Triglycerides (TG), alanine transaminase (ALT), aspartate transaminase (AST), and uric acid were steady risk factors for NAFLD in males. Total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), ALT, and uric acid were steady risk factors for NAFLD in females. TG, ALT and uric acid were common risk factors in both genders with high performance for NAFLD discrimination. Our data provide gender- and BMI-specific risk factor compositions that will facilitate individualised treatment and benefit NAFLD control and prevention.

Highlights

Fatty liver refers to hepatic steatosis accounting for more than 5–10% of the total weight of the liver or macrosteatosis of the same extent in histopathology [1]
The percentages of subjects with nonalcoholic fatty liver disease (NAFLD) increased from 0.4% in the underweight group to 82.4% in the obese group
The body mass index (BMI), age, male ratio, systolic pressure, diastolic pressure, serum levels of Total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), glucose, alanine transaminase (ALT), aspartate transaminase (AST), urea nitrogen, uric acid and creatinine were higher in groups with higher BMI

Summary

Introduction

Fatty liver refers to hepatic steatosis accounting for more than 5–10% of the total weight of the liver or macrosteatosis of the same extent in histopathology [1]. Up to 75% of individuals with NAFLD are patients with isolated hepatic steatosis or with steatosis concomitant of mild nonspecific inflammation; up to 25% of individuals with NAFLD have NASH [4,5,6,7]. Stages of isolated hepatic steatosis, steatosis with mild lobular inflammation and NASH can evolve as each other and patients with NASH have a high risk of developing liver fibrosis and liver cirrhosis [1,2,3,4,5,6,7]. Insulin resistance, hypertension, weight gain and increasing alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are known risk factors for disease progression from NASH to liver fibrosis [4]. The impact of NAFLD on liver disease is receiving increasing attention

Methods

Results

Conclusion