Abstract
PurposeTo classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP).MethodsThe medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewed. Twenty potential risk factors that may influence the development or progression of ROP were analyzed by univariate and multivariate logistic regression analyses. The progression of ROP was defined as type 1 ROP, threshold ROP, or aggressive posterior ROP for which treatment was recommended.ResultsA total of 324 eyes were included; 157 eyes (48.5%) showed ROP development, and 48 eyes exhibited ROP progression (14.8% of all eyes and 30.6% of the ROP-developed eyes). According to the univariate and multivariate logistic regression analyses, prenatal steroid use, GA, the duration of mechanical ventilation, and respiratory distress syndrome were associated with the development of ROP. However, GA, bronchopulmonary dysplasia, the number of red blood cell units transfused, intraventricular hemorrhage, and periventricular leukomalacia were significantly correlated with ROP progression.ConclusionThe risk factors that influenced ROP development versus ROP progression were not identical. Evaluating these risk factors during screening of high-risk premature infants will help determine the appropriate timing of examinations and treatment.
Highlights
Retinopathy of prematurity (ROP) is a vasoproliferative disease of the developing retina of premature infants.[1]
According to the univariate and multivariate logistic regression analyses, prenatal steroid use, gestational age (GA), the duration of mechanical ventilation, and respiratory distress syndrome were associated with the development of ROP
GA, bronchopulmonary dysplasia, the number of red blood cell units transfused, intraventricular hemorrhage, and periventricular leukomalacia were significantly correlated with ROP progression
Summary
Retinopathy of prematurity (ROP) is a vasoproliferative disease of the developing retina of premature infants.[1]. Examinations and treatment plans for ROP should be carefully devised by considering the risk factors for ROP development and progression, and the risk factors of ROP development must be distinguished from those of ROP progression. ROP is a multifactorial disease, and several risk factors have been analyzed in numerous studies. Few studies have distinguished the risk factors of ROP development from those of ROP progression. The potential risk factors for ROP were analyzed to determine which risk factors influence ROP development versus ROP progression
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