Risk Calculator for Retinopathy of Prematurity Requiring Treatment.

Maria J Chaves-Samaniego,Jose L García-Serrano,Jose Maria Ortega Molina,Ana Solans Perez Larraya,Maria C Chaves-Samaniego,Mar García Castejón,Antonio Muñoz Hoyos

doi:10.3389/fped.2020.529639

Abstract

Importance: Vascular delay that occurs early in the development of retinopathy of prematurity (ROP) is a risk factor that can be compensated by ensuring a good rate of retinal vascularization to avoid ROP that requires treatment.Background: The objective of the present study was to determine the association between ROP that requires treatment and risk factors such as the extent of the temporal avascular area of the retina and the number of days of mechanical ventilation (MV).Design: Observational retrospective case-control study.Participants: Two hundred and twenty-eight premature newborns included in the screening protocol for retinopathy of prematurity.Methods: Subjects underwent retinal examination in the 4 and 6th postnatal weeks.Main Outcome Measures: The temporal avascular area was measured in disc diameters (DD), while the MV time was measured in days of treatment.Results: Patients with a longer MV time had a higher risk of treatment (R2: 24.7, p < 0.0001; increase in risk of 8.1% for each additional day), as did those who showed greater avascular area (R2: 24.7, p < 0.0001; increase in risk of 111% for each additional DD). An online calculator system and a table are presented for calculating the risk of ROP requiring treatment as a function of these two risk factors.Conclusions and Relevance: The temporal avascular area of the retina and MV time must be taken into account in the first examination of the newborn to predict the need for ROP treatment.

Highlights

Retinopathy of prematurity (ROP) is currently the world’s second leading cause of preventable child blindness [1, 2]
Authors themselves have made clarifications regarding their own models, claiming that no predictive model will work properly at a universal level [11]; in many cases newborns of ≥31 weeks or
The mean GA of the study population was 28.83 ± 2.03 weeks; 34.6% of the newborns had a gestational age of 24–27 weeks, 47.4% of 28–30 weeks, and 18% of 31–34 weeks

Summary

Introduction

Retinopathy of prematurity (ROP) is currently the world’s second leading cause of preventable child blindness [1, 2]. For this reason, numerous studies have been carried out to identify the main risk factors for ROP [3] and incorporate them into early ROP detection algorithms [4]. The objective of the present study was to determine the association between ROP that requires treatment and risk factors such as the extent of the temporal avascular area of the retina and the number of days of mechanical ventilation (MV)

Objectives

Methods

Results

Conclusion