Abstract
Receptor interacting protein 140 (RIP140), gene named Nuclear receptor interacting protein 1 (Nrip1), is a transcription co-regulator of numerous nuclear receptors and transcription factors that are important for various biological processes
Highlights
Receptor interacting protein Receptor interacting protein 140 (RIP140) (RIP140, gene name Nuclear receptor interacting protein 1 (Nrip1)) is a versatile transcriptional co-regulator of numerous nuclear receptors and transcription factors[1,2]
Using primary astrocyte cell cultures as experimental systems, we have found that Endoplasmic Reticulum (ER) stress directly inhibits RIP140 mRNA expression via increasing microRNA 3316 which targets the mRNA’s 3’-untranslated region of RIP14058
ER stress induced by thapsigargin, dithiothreitol, and brefeldin A promotes rapid RIP140 translocation to cytoplasm in hippocampal neurons where it is required for toning down the extent of ER stress-induced IP3R activity, protecting cells from apoptosis[20]
Summary
Receptor interacting protein RIP140 (RIP140, gene name Nrip1) is a versatile transcriptional co-regulator of numerous nuclear receptors and transcription factors[1,2]. RIP140 is expressed in neurons, microglia and astrocytes, indicating extensive functional roles for RIP140 in This review focuses on RIP140’s functional roles in three major brain cell types, neurons, microglia and astrocytes.
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