Ring-opening reactions of the anticancer drug carboplatin: NMR characterization of cis-[Pt(NH3)2(CBDCA-O)(5'-GMP-N7)] in solution

Abstract

We have studied reactions of the anticancer drug (Pt(NH 3 ) 2 (CBDCA-O,O'] (carboplatin, «Paraplatin», where H 2 CBDCA is cyclobutane-1,1-dicarboxylic acid) with nitrate, phosphate, chloride, and 5'-guanosine monophosphate (5'-GMP) in aqueous solution at 310 K using 1 H, 15 N, ( 1 H, 15 N], and 31 P NMR spectroscopy. A structure for cis-(Pt(NH 3 ) 2 (CBDCA-O)(5'-GMP)] is proposed which accounts for the inequivalence of all six cyclobutane ring protons in this complex.