Abstract
Polymerization-induced self-assembly (PISA) is regarded as one of the most important strategies in macromolecular nanotechnology, as it can create a wide range of nanoparticles at high concentrations and on a large scale. However, open-to-air PISA with biodegradable product is still a complicated challenge, as traditional PISA is usually carried out under oxygen-free conditions to afford nonbiodegradable polymers. To meet the above challenges, we propose a convenient one-pot open-to-air ring-opening polymerization (ROP) of N-carboxyanhydride (NCA)-induced self-assembly (NCA-PISA) at 10 °C, without the need for degassing, heating, catalysts, or chain transfer agents. The morphologies of nanoparticles depend on the ratio of the initiator to the monomer and the solid content. Polymer vesicles can be fabricated when the ratio and the solid content are 1:20 and 20%, respectively. Overall, this versatile one-pot NCA-PISA provides an insight into facilely fabricating biodegradable nanoparticles in air.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.