Abstract
The P-nucleophilic ring-opening of oxazolines is a highly desired but rarely reported reaction. We have developed a ring-opening phosphanylation of oxazolines using lithium diphenylphosphanide as the nucleophile without loss of optical purity. This methodology is compatible with various chiral pyridine-oxazolines bearing different substituents and features the advantage of mild conditions with easy operation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have